A Phase I/II Study of Lenalidomide and Obinutuzumab With CHOP for Diffuse Large B Cell Lymphoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

November 4, 2015

Primary Completion Date

October 31, 2022

Study Completion Date

October 31, 2022

Conditions
Lymphoma
Interventions
DRUG

Lenalidomide

"Phase I Starting Dose Level: 15 mg by mouth on Days 1 - 14 of each 21 day cycle.~Phase II Starting Dose Level: Maximum tolerated dose from Phase I."

DRUG

Obinutuzumab

Phase I and II: 1000 mg by vein on Days 1, 8, and 15 of Cycle 1 and Day 1 of Cycles 2 - 6.

DRUG

Cyclophosphamide

Phase I and II: 750 mg/m2 vein over about 1 hour on Day 1 of all cycles.

DRUG

Doxorubicin

Phase I and II: 50 mg/m2 by vein over about 15 minutes each on Day 1 of all cycles.

DRUG

Vincristine

Phase I and II: 1.4 mg/m2 by vein on Day 1 of all cycles.

DRUG

Prednisone

Phase I and II: 100 mg by mouth daily on Days 1 - 5 of each 21 day cycle.

Trial Locations (1)

77030

University of Texas MD Anderson Cancer Center, Houston

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

M.D. Anderson Cancer Center

OTHER