A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

433

Participants

Timeline

Start Date

October 19, 2015

Primary Completion Date

November 6, 2020

Study Completion Date

April 1, 2026

Conditions
Hepatocellular Carcinoma
Interventions
BIOLOGICAL

Tremelimumab

Tremelimumab will be administered by IV infusion according to doses and frequency mentioned in arms' description.

BIOLOGICAL

Durvalumab

Durvalumab will be administered by IV infusion according to doses and frequency mentioned in arms' description.

BIOLOGICAL

Bevacizumab

Bevacizumab 15 mg/kg will be administered by IV infusion every 3 weeks until confirmed progressive disease, withdrawal of consent, lost to follow-up, or development of other reason for treatment discontinuation, whichever occurred first.

Trial Locations (44)

100

Research Site, Taipei

333

Research Site, Taoyuan

10065

Research Site, New York

11794

Research Site, Stony Brook

13620

Research Site, Seongnam-si

14004

Research Site, Córdoba

19107

Research Site, Philadelphia

19111

Research Site, Philadelphia

20133

Research Site, Milan

27705

Research Site, Durham

31008

Research Site, Pamplona

32224

Research Site, Jacksonville

33612

Research Site, Tampa

37203

Research Site, Nashville

41944

Research Site, Junggu

46202

Research Site, Indianapolis

49241

Research Site, Busan

75390

Research Site, Dallas

82100

Research Site, Benevento

83301

Research Site, Kaohsiung City

85054

Research Site, Phoenix

94158

Research Site, San Francisco

97213

Research Site, Portland

98109

Research Site, Seattle

119074

Research Site, Singapore

169610

Research Site, Bukit Merah

200032

Research Site, Shanghai

210002

Research Site, Nanjing

308433

Research Site, Singapore

310016

Research Site, Hangzhou

06510

Research Site, New Haven

02114

Research Site, Boston

Unknown

Research Site, Hong Kong

Research Site, Shatin

00168

Research Site, Roma

104-0045

Research Site, Chūōku

277-8577

Research Site, Kashiwa

589-8511

Research Site, Osakasayama-shi

03080

Research Site, Seoul

05505

Research Site, Seoul

06273

Research Site, Seoul

06351

Research Site, Seoul

08035

Research Site, Barcelona

08036

Research Site, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MedImmune LLC

INDUSTRY