Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 443139 in Participants With Early Manifest Huntington's Disease

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

August 6, 2015

Primary Completion Date

November 8, 2017

Study Completion Date

November 8, 2017

Conditions
Huntington's Disease
Interventions
DRUG

ISIS 443139 10 mg

ISIS 443139, 10 mg, was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

DRUG

ISIS 443139 30 mg

ISIS 443139, 30 mg, was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

DRUG

ISIS 443139 60 mg

ISIS 443139, 60 mg, was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

DRUG

ISIS 443139 90 mg

ISIS 443139, 90 mg, was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

DRUG

ISIS 443139 120 mg

ISIS 443139, 120 mg, was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

OTHER

Placebo

Placebo was administered by intrathecal injection, on Study Days 1, 29, 57, and 85.

Trial Locations (9)

10117

Charite University Berlin, Berlin

44791

Ruhr-University of Bochum, Bochum

89081

Ulm University Hospital, Ulm

V6T 2B5

University of British Columbia, Vancouver

B15 2TH

University Hospitals Birmingham, Birmingham

CB2 0PY

Cambridge University Hospital, Cambridge

CF14 4XN

University Hospital of Wales, Cardiff

WC1N 3BG

University College London, London

M13 9WL

University of Manchester, St. Mary's Hospital, Manchester

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY