Comparative Bioavailability Study of Two Misoprostol Formulations

One tablet of Angusta™ (25 µg) given every 2 hours

1/8 of a tablet of Cytotec® (25 µg) given every 2 hours. Drug administration should be repeated every 2 hours until labour has commenced.

Two tablets of Angusta™ 25 µg given every 4 hours

¼ of a tablet of Cytotec® given every 4 hours. Drug administration should be repeated every 4 hours until labour has commenced.

Two tablets of Angusta™ (total dose of 50 µg), given every 4 hours

¼ of a tablet of Cytotec® (50 µg), given every 4 hours. Subjects should not swallow for a period of 5 minutes. Drug administration should be repeated every 4 hours until labour has commenced.