MEK and MET Inhibition in Colorectal Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

November 30, 2014

Primary Completion Date

December 3, 2018

Study Completion Date

December 3, 2018

Conditions
Solid TumorColorectal Cancer
Interventions
DRUG

PF-02341066

PF-02341066 (Crizotinib) 250mg OD or 200mg BD or 250mg BD Days 1-28 continuously

DRUG

PD-0325901

PD-0325901 2mg - 8mg BD with Run in Day -7 to Day-1 on Cycle 1 Day1, then Day 1-21 every 28 day cycle.

DRUG

Binimetinib

Binimetinib 30mg or 45 mg BD either continuously or Days 1-21 every 28 days

Trial Locations (1)

OX3 7LE

Oxford University Hospital NHS Trust, Oxford

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Queen's University, Belfast

OTHER

collaborator

Oxford University Hospitals NHS Trust

OTHER

collaborator

Velindre NHS Trust

OTHER_GOV

collaborator

University Hospital, Antwerp

OTHER

collaborator

Hospital Vall d'Hebron

OTHER

collaborator

Saint Antoine University Hospital

OTHER

collaborator

European Georges Pompidou Hospital

OTHER

collaborator

Pfizer

INDUSTRY

collaborator

University of Turin, Italy

OTHER

collaborator

Belfast Health and Social Care Trust

OTHER

collaborator

Beaumont Hospital

OTHER

collaborator

European Commission

OTHER

collaborator

Array BioPharma

INDUSTRY

collaborator

University of Paris 5 - Rene Descartes

OTHER

lead

University of Oxford

OTHER

NCT02510001 - MEK and MET Inhibition in Colorectal Cancer | Biotech Hunter | Biotech Hunter