Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

May 11, 2016

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Metastatic Lung Non-Small Cell CarcinomaRecurrent Lung Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Elastography

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

BIOLOGICAL

Necitumumab

Given IV

DRUG

Osimertinib

Given PO

Trial Locations (15)

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20007

MedStar Georgetown University Hospital, Washington D.C.

27518

Duke Cancer Center Cary, Cary

27710

Duke University Medical Center, Durham

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

80045

UCHealth University of Colorado Hospital, Aurora

91010

City of Hope Comprehensive Cancer Center, Duarte

94304

Stanford Cancer Institute Palo Alto, Palo Alto

95817

University of California Davis Comprehensive Cancer Center, Sacramento

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH