Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy

PHASE1CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

July 31, 2015

Primary Completion Date

August 31, 2016

Study Completion Date

August 31, 2016

Conditions
Progressive Supranuclear Palsy
Interventions
DRUG

Single dose C2N-8E12

C2N-8E12 is a humanized recombinant anti-human tau antibody.

DRUG

Single dose placebo

Subjects will be block randomized to receive a single dose of C2N-8E12 or placebo in two blocks of 4 subjects (3:1, C2N-8E12:placebo) per cohort.

Trial Locations (12)

32224

Mayo Clinic, Jacksonville

32607

University of Florida College of Medicine, Gainesville

35294

University of Alabama, Birmingham

46202

Indiana University Medical Center, Indianapolis

55905

Mayo Clinic, Rochester

75231

Texas Health Presbyterian Dallas, Dallas

85259

Mayo Clinic, Scottsdale

90095

University of California, Los Angeles (UCLA), Los Angeles

92037

UCSD Department of Neurosciences, San Diego

94158

University of California, San Francisco, San Francisco

10032-3795

Columbia University, New York

37232-2551

Vanderbilt University Medical Center, Nashville

Sponsors

Lead Sponsor

All Listed Sponsors
lead

C2N Diagnostics

INDUSTRY

NCT02494024 - Safety, Tolerability, and Pharmacokinetics of C2N-8E12 in Subjects With Progressive Supranuclear Palsy | Biotech Hunter | Biotech Hunter