Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

May 20, 2015

Primary Completion Date

September 30, 2022

Study Completion Date

November 24, 2022

Conditions
Neoplasms
Interventions
DRUG

Lisavanbulin Phase 1 dose escalation portion

Lisavanbulin hard capsules, containing 1 mg or 5 mg study drug, were given orally to fasted patients once daily in the dose range of 2 to 35 mg/day

DRUG

Lisavanbulin Phase 2a expansion portion

Recommended Phase 2 dose (RP2D) of 25 mg/day lisavanbulin hard capsules containing 5 mg study drug was administered once daily.

Trial Locations (13)

3000

UZ Leuven, Leuven

3010

Inselspital Universitätsspital Bern, Bern

4031

Universitätsspital Basel, Basel

8091

Universitätsspital Zürich, Zurich

9007

Kantonsspital St. Gallen, Sankt Gallen

60528

Klinikum der Goethe-Universität Frankfurt, Frankfurt

69120

Universitätsklinikum Heidelberg, Heidelberg

72076

Universitätsklinikum Tübingen, Tübingen

93053

Universitätsklinikum Regensburg, Regensburg

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

NW1 2BU

University College London NHS Foundation Trust, London

NE7 7DN

Sir Bobby Robson Cancer Trials Research Centre; Northern Centre for Cancer Care, Newcastle upon Tyne

SM2 5PT

Royal Marsden Hospital, Sutton

Sponsors
All Listed Sponsors
lead

Basilea Pharmaceutica

INDUSTRY