Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis

PHASE2UnknownINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

October 31, 2014

Primary Completion Date

September 30, 2015

Study Completion Date

September 30, 2015

Conditions
Liver Dysfunction
Interventions
DRUG

Mivacurium Chloride

"Anesthesia induction:~Intravenous injection of midazolam 0.05 mg/kg,Etomidate 0.3 mg/kg,Sufentanil 0.5 g/kg,TOF detection and adjustment of the first twitch height (T1)100%, Mivacurium Chloramine 0.07 mg/kg intraveous injecting in 5 minutes.~Anesthesia maintenance:~Two groups of sevoflurance 1%\~8% inhalation anesthesia plus intravenous infusion of remifentanil 0.05~0.2 µg/kg/min,Mivacurium Chloramine 6mg/kg/h, Appropriate supplementary analgesia dose of sufentanil before skin incision and the abdomen was closed. The two groups were maintained until the Bis value was 40 \~ 60. PetCO2 was 30 \~ 35mmHg. Hemodynamic fluctuations did not exceed 20% of the baseline value.At least 20 minutes before the operation stopping Mivacurium infusion,Before the end of operation 5-10 minutes stopping infusion of remifentanil and sevoflurane."

Trial Locations (1)

710038

RECRUITING

Tangdu hospital, Xi’an

Sponsors
All Listed Sponsors
collaborator

Jiangsu Nhwa Pharmaceutical Co., Ltd.

INDUSTRY

lead

Tang-Du Hospital

OTHER

NCT02473601 - Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis | Biotech Hunter | Biotech Hunter