KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma

KPT-330 administered orally on days -5 and -3 prior to starting chemotherapy. Once chemotherapy starts, KPT-330 will be administered on days 1, 3, and 5 of each cycle. Dose levels will range from 20 mg to 100mg with a standard 3+3 escalation schema.

IV Rituximab 375 mg/m2 on D1

IV Etoposide 100 mg/m2 on D1-3

IV Carboplatin AUC 5 on D2

IV Ifosfamide 5 g/m2 on D2

20 mg qd on Days -5 and -3. 20 mg qd on Days 1-5