Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction

PHASE3CompletedINTERVENTIONAL
Enrollment

225

Participants

Timeline

Start Date

June 15, 2015

Primary Completion Date

February 8, 2019

Study Completion Date

February 18, 2021

Conditions
Heart Failure With Reduced Ejection Fraction (HF-rEF)
Interventions
DRUG

LCZ696

The target dose during the study was LCZ696 200 mg bid given orally. LCZ696 was supplied as 50 mg, 100 mg and 200 mg film-coated tablets.

DRUG

Enalapril

The target dose during the study was enalapril 10 mg bid given orally. Enalapril was provided as 2.5 mg, 5 mg, and 10 mg tablets.

DRUG

Placebo to LCZ696

LCZ696 Placebo 50 mg, 100 mg and 200 mg film-coated tablets

DRUG

Placebo to Enalapril

Enalapril Placebo 2.5 mg, 5 mg and 10 mg tablets

Trial Locations (49)

3850051

Novartis Investigative Site, Saku

453-8511

Novartis Investigative Site, Nagoya

489-8642

Novartis Investigative Site, Seto

818-8516

Novartis Investigative Site, Chikushino-shi

810-0001

Novartis Investigative Site, Fukuoka

812-8582

Novartis Investigative Site, Fukuoka

820-8505

Novartis Investigative Site, Iizuka

830-8577

Novartis Investigative Site, Kurume

960 1295

Novartis Investigative Site, Fukushima

963-8052

Novartis Investigative Site, Kōriyama

371 8511

Novartis Investigative Site, Maebashi

738 8503

Novartis Investigative Site, Hatsukaichi

078-8211

Novartis Investigative Site, Asahikawa

047-8510

Novartis Investigative Site, Otaru

060 8648

Novartis Investigative Site, Sapporo

660 8550

Novartis Investigative Site, Amagasaki

665-0873

Novartis Investigative Site, Takarazuka

020 0066

Novartis Investigative Site, Morioka

760 8557

Novartis Investigative Site, Takamatsu

211-8533

Novartis Investigative Site, Kawasaki

216-8511

Novartis Investigative Site, Kawasaki

227-8501

Novartis Investigative Site, Yokohama

860-8556

Novartis Investigative Site, Kumamoto

607-8062

Novartis Investigative Site, Kyoto

611-0042

Novartis Investigative Site, Uji

980 8574

Novartis Investigative Site, Sendai

880-2102

Novartis Investigative Site, Miyazaki

634 8522

Novartis Investigative Site, Kashihara

870-0192

Novartis Investigative Site, Ōita

700-8558

Novartis Investigative Site, Okayama

596-0042

Novartis Investigative Site, Kishiwada

530-8480

Novartis Investigative Site, Osaka

559-0012

Novartis Investigative Site, Osaka

569-1096

Novartis Investigative Site, Takatsuki

560-8565

Novartis Investigative Site, Toyonaka

359-1141

Novartis Investigative Site, Tokorozawa

525 8585

Novartis Investigative Site, Kusatsu

420-8630

Novartis Investigative Site, Shizuoka

329-0498

Novartis Investigative Site, Shimotsuke

113-8603

Novartis Investigative Site, Bunkyo-ku

101-8309

Novartis Investigative Site, Chiyoda-ku

104-8560

Novartis Investigative Site, Chuo Ku

192-0918

Novartis Investigative Site, Hachiōji

173-8610

Novartis Investigative Site, Itabashi-ku

142-8666

Novartis Investigative Site, Shinagawa-ku

683-8504

Novartis Investigative Site, Yonago

745-8522

Novartis Investigative Site, Shūnan

400-8506

Novartis Investigative Site, Kofu

330 8503

Novartis Investigative Site, Saitama

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY