Study of Docetaxel or Vinorelbine Plus Cisplatin in Neoadjuvant Chemoradiotherapy for Esophageal Cancer (NEOCRTEC308)

25mg/ m2 Docetaxel dose administered on days 1, 8, 15, and 22.

25mg/ m2 on days 1, 8, 15 and 22.

Patient will receive 4 weeks of radiation therapy (44 Gy/20 fractions).

McKeown esophagectomy, Ivor Lewis esophagectomy or minimally invasive esophagectomy will be performed 4-8 weeks after chemoradiotherapy. Two-field lymphadenectomy with total mediastinal lymph node dissection is performed during surgery.

25mg/ m2 on days 1, 8 of each cycle (i.e. every 21 days).

75mg/ m2 on day 1 of each cycle only (i.e. every 21 days).