NCT02458729 - The Blood Saving Effect of Tranexamic Acid in Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis | Biotech Hunter

Enrollment

294

Participants

Timeline

Start Date

August 31, 2012

Primary Completion Date

July 31, 2014

Study Completion Date

July 31, 2014

Conditions

Osteoarthritis, Knee

Interventions

DRUG

Tranexamic Acid 5%,5ml/amp (intraoperative)

tranexamic acid 1g administered intravenously five minutes before deflation of the tourniquet

DRUG

Tranexamic Acid 5%,5ml/amp (3 hours after operation)

tranexamic acid 1g administered intravenously 3 hours after operation

DRUG

0.9% Normal Saline (intraoperative)

0.9% Normal Saline 20ml administered intravenously five minutes before deflation of the tourniquet

DRUG

0.9% Normal Saline (3 hours after operation)

0.9% Normal Saline 20ml administered intravenously 3 hours after operation

DRUG

rivaroxaban (10mg)

Oral rivaroxabam (10mg) QD on PostOp Day 1 to 14

Trial Locations (1)

Kaohsiung Chang Gung Memorial Hospital, Koahsiung

All Listed Sponsors

lead

Chang Gung Memorial Hospital

OTHER