A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

July 31, 2015

Primary Completion Date

January 31, 2016

Study Completion Date

March 31, 2016

Conditions
Heart Failure
Interventions
DRUG

BAY1142524

5 mg BAY1142524 or placebo given as 5 mg IR tablet twice daily for 2 weeks

DRUG

BAY1142524

10 mg BAY1142524 or placebo given as 2 x 5 mg IR tablets twice daily as for 2 weeks

DRUG

BAY1142524

25 mg BAY1142524 or placebo given as 5 x 5 mg IR tablets twice daily for 2 weeks

DRUG

BAY1142524

50 mg BAY1142524 or placebo given 1 x 50 mg IR tablet once daily for 2 weeks

DRUG

Placebo

The patients will be treated orally with combinations of IR tablets containing placebo to achieve the indicated dosages.

Trial Locations (10)

2100

Copenhagen Ø

2730

Herlev

2900

Hellerup

13353

Berlin

24127

Bergamo

25123

Brescia

40225

Düsseldorf

60594

Frankfurt am Main

99084

Erfurt

DK-2400

Copenhagen

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY