A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD

PHASE2CompletedINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

January 31, 2014

Primary Completion Date

December 8, 2017

Study Completion Date

December 28, 2017

Conditions
EpilepsyTuberous Sclerosis ComplexFocal Cortical Dysplasia
Interventions
DRUG

Everolimus

This study will measure if the drug called Everolimus effects mTOR signaling (an electrical activity signal in the brain) in patients with Tuberous Sclerosis Complex (TSC) and Focal Cortical Dysplasia (FCD) with treatment resistant epilepsy (TRE) who will be undergoing brain surgery. One group of patients will be treated with Everolimus, for 7-28 days prior to epilepsy surgery and another will not. We will determine if there is a difference in mTOR signaling between the patients who were treated with Everolimus and those who were not

Trial Locations (1)

10016

New York University Langone Medical Center, New York

All Listed Sponsors
lead

NYU Langone Health

OTHER

NCT02451696 - A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD | Biotech Hunter | Biotech Hunter