Neural and Psychological Mechanisms of Pain Perception

NARecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

June 11, 2015

Primary Completion Date

February 20, 2026

Study Completion Date

February 20, 2026

Conditions
PainNormal PhysiologyHealthy Volunteers
Interventions
BEHAVIORAL

Instructions

In sub-study 1, half the participants are instructed about outcomes, half learn through experience.

BEHAVIORAL

Attention

In sub-study 4, participants learn about outcomes and we manipulate attention toward or away from the pain.

BEHAVIORAL

Thermal Pain

In sub-studies 2 and 3, participants are exposed to thermal stimuli and/or tastants (sugar water, salt water, neutral rinse) and we are measuring how learning varies based on the type of outcome.

BEHAVIORAL

Placebo instructions

In sub-study 5, we test whether placebo effects and expectancy cues modulate pain through similar mechanisms.

Trial Locations (1)

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
lead

National Center for Complementary and Integrative Health (NCCIH)

NIH