Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expansion Cohorts in NSCLC, Melanoma, and Colorectal Cancer (CRC)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

191

Participants

Timeline

Start Date

August 26, 2015

Primary Completion Date

September 29, 2022

Study Completion Date

September 29, 2022

Conditions
Non-Small Cell Lung CancerMelanomaMismatch Repair-Proficient Colorectal Cancer
Interventions
DRUG

entinostat

An orally available histone deacetylases inhibitor (HDACs)

DRUG

pembrolizumab

A selective humanized monoclonal antibody (mAb)

Trial Locations (11)

10065

Memorial Sloan Kettering Cancer Center, New York

14263

Roswell Park Cancer Institute, Buffalo

18045

St Luke's University Health Network, Easton

21201

University of Maryland, Marlene and Stewart Greenbaum Cancer Center, Baltimore

21231

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

27599

The University of North Carolina at Chapel Hill, Chapel Hill

30322

Emory University, Atlanta

37203

Sarah Cannon Research Institute, Nashville

37230

Vanderbilt University Medical Center, Nashville

06519

Yale University, New Haven

02215

Dana Farber Cancer Institution, Boston

Sponsors
All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Syndax Pharmaceuticals

INDUSTRY