Safety and Durability of Sirolimus for Treatment of LAM

RecruitingOBSERVATIONAL
Enrollment

600

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

July 31, 2025

Study Completion Date

July 31, 2025

Conditions
Lymphangioleiomyomatosis
Interventions
DRUG

Sirolimus

Sirolimus treatment will be part of a participant's clinical care and will be managed by their physician.

DRUG

Everolimus

Everolimus treatment will be part of a participant's clinical care and will be managed by their physician.

Trial Locations (20)

19104

ACTIVE_NOT_RECRUITING

University of Pennsylvania Medical Center, Philadelphia

29425

ACTIVE_NOT_RECRUITING

Medical University of South Carolina, Charleston

32224

RECRUITING

Mayo Clinic Jacksonville, Jacksonville

33136

RECRUITING

Emory University School of Medicine, Atlanta

44195

ACTIVE_NOT_RECRUITING

Cleveland Clinic, Cleveland

45267

ACTIVE_NOT_RECRUITING

University of Cincinnati, Cincinnati

48109

RECRUITING

University of Michigan, Ann Arbor

55905

ACTIVE_NOT_RECRUITING

Mayo Clinic Rochester, Rochester

60153

ACTIVE_NOT_RECRUITING

Loyola University Medical Center, Chicago, Maywood

63110

RECRUITING

Washington University School of Medicine, St Louis

75390

ACTIVE_NOT_RECRUITING

University of Texas Southwestern Medical Center, Dallas

77030

ACTIVE_NOT_RECRUITING

University of Texas Health Center, Houston

80206

RECRUITING

National Jewish Health, Denver

84132

ACTIVE_NOT_RECRUITING

University of Utah School of Medicine, Salt Lake City

94305

RECRUITING

Stanford University Medical Center, Stanford

97239

ACTIVE_NOT_RECRUITING

Oregon Health and Science University, Portland

98104

ACTIVE_NOT_RECRUITING

Swedish Medical Center, Seattle

02115

RECRUITING

Brigham and Women's Hospital, Boston

14642-8692

RECRUITING

University of Rochester Medical Center, Rochester

37232-2650

ACTIVE_NOT_RECRUITING

Vanderbilt University Medical Center, Nashville

All Listed Sponsors
collaborator

Rare Diseases Clinical Research Network

NETWORK

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

The LAM Foundation

OTHER

lead

University of Cincinnati

OTHER