Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor

PHASE2CompletedINTERVENTIONAL
Enrollment

107

Participants

Timeline

Start Date

August 28, 2015

Primary Completion Date

April 26, 2018

Study Completion Date

February 7, 2020

Conditions
Myelofibrosis
Interventions
DRUG

Imetelstat 4.7 mg/kg

Participants received imetelstat 4.7 mg/kg of body weight as intravenous infusion on Day 1 of each 21-day cycle. Study drug was administered intravenously until disease progression, unacceptable toxicity, or study end.

DRUG

Imetelstat 9.4 mg/kg

Participants received imetelstat 9.4 mg/kg of body weight as intravenous infusion on Day 1 of each 21-day cycle until disease progression, unacceptable toxicity, or study end.

Trial Locations (72)

Unknown

Birmingham

Duarte

La Jolla

Los Angeles

Stanford

Washington D.C.

Tampa

West Palm Beach

Chicago

Louisville

Baltimore

Ann Arbor

Rochester

St Louis

Buffalo

Lake Success

New York

The Bronx

Charlotte

Durham

Winston-Salem

Cincinnati

Philadelphia

Greenville

Watertown

Nashville

Dallas

Seattle

Milwaukee

Antwerp

Bruges

Brussels

Leuven

Edmonton

Winnipeg

Montreal

Angers

Lille

Marseille

Paris

Pierre-Bénite

Toulouse

Aachen

Cologne

Dresden

Düsseldorf

Frankfurt

Hamburg

Heidelberg

Leipzig

Mannheim

Rostock

Haifa

Jerusalem

Kfar Saba

Nahariya

Ramat Gan

Tel Aviv

Bergamo

Bologna

Seoul

Barcelona

Las Palmas de Gran Canaria

Madrid

Salamanca

Valencia

Chiayi City

Taipei

Birmingham

Glasgow

London

Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Geron Corporation

INDUSTRY

NCT02426086 - Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor | Biotech Hunter | Biotech Hunter