A Study to Assess the Safety and Pharmacokinetics of MOXR0916 and Atezolizumab (Also Known as MPDL3280A or Anti-PD-L1) in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

610

Participants

Timeline

Start Date

April 24, 2015

Primary Completion Date

November 22, 2019

Study Completion Date

November 22, 2019

Conditions
Neoplasms
Interventions
DRUG

Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 [PD-L1] antibody

Atezolizumab will be administered intravenously.

DRUG

MOXR0916, a humanized agonist anti-OX40 monoclonal antibody

MOXR0916 will be administered intravenously.

Trial Locations (27)

1070

Institut Jules Bordet, Anderlecht

2050

Chris O'Brien Lifehouse, Camperdown

2610

Sint Augustinus Wilrijk, Wilrijk

3000

Peter Maccallum Cancer Centre, Melbourne

3084

Austin Hospital, Heidelberg

6009

Sir Charles Gairdner Hospital, Nedlands

9000

UZ Gent, Ghent

20007

Georgetown University Medical Center Lombardi Cancer Center, Washington D.C.

28050

Hosp de Madrid Norte Sanchinarro; Centro Integral; Onco Clara Campal, Madrid

31008

Clinica Universitaria de Navarra, Pamplona

37203

Sarah Cannon Research Institute, Nashville

46010

Hospital Clinico Universitario de Valencia, Valencia

60637

University Of Chicago Medical Center; Section Of Hematology/Oncology, Chicago

85258

HonorHealth Research Institute - Bisgrove, Scottsdale

94800

Gustave Roussy, Villejuif

98109

Seattle Cancer Care Alliance, Seattle

80045-2517

University of Colorado, Aurora

06510

Yale School of Medicine, New Haven

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Can Ins, Boston

V5Z 4E6

British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver

M5G 2M9

University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto

H3T 1E2

McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

120-752

Yonsei University Health System/Severance Hospital, Seoul

08035

Hospital Universitari Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY