Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

March 31, 2014

Primary Completion Date

May 31, 2016

Study Completion Date

May 31, 2017

Conditions
Heart Failure, DiastolicAortic Valve StenosisMonitoring, PhysiologicPhysiology
Interventions
DRUG

Levosimendan

"Data is collected at baseline as two controls.~Three physiological interventions follows, and data is collected after each:~Increasing heart rate in two steps by atrial pacing through a temporary pacemaker.~Raising cardiac preload by increasing central venous pressure through leg elevation.~Raising cardiac afterload by increasing systemic vascular resistance through administering of phenylephrine.~Baseline is restored, and data is collected before drug adminstration as two controls, then after a first (half) dose, and finally after a second (full) dose."

DRUG

Milrinone

"Data is collected at baseline as two controls.~Three physiological interventions follows, and data is collected after each:~Increasing heart rate in two steps by atrial pacing through a temporary pacemaker.~Raising cardiac preload by increasing central venous pressure through leg elevation.~Raising cardiac afterload by increasing systemic vascular resistance through administering of phenylephrine.~Baseline is restored, and data is collected before drug adminstration as two controls, then after a first (half) dose, and finally after a second (full) dose."

Trial Locations (1)

413 45

Thoraxoperation/TIVA, Sahlgrenska universitetssjukhuset, Gothenburg

All Listed Sponsors
lead

Sahlgrenska University Hospital

OTHER

NCT02408003 - Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support. | Biotech Hunter | Biotech Hunter