Study of the Safety, Pharmacokinetics and Antitumor Activities of BGB-A317 in Participants With Advanced Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

451

Participants

Timeline

Start Date

June 2, 2015

Primary Completion Date

August 12, 2020

Study Completion Date

August 12, 2020

Conditions
Advanced Cancer
Interventions
BIOLOGICAL

BGB-A317

In the dose escalation part, the dose levels were escalated following a modified 3+3 dose escalation scheme. In the scheduled exploration part, participants were assigned to doses and dose schedules. In the fixed dose exploration part, participants were assigned to dose group(s) not to exceed the maximum tolerated dose. In the dose expansion part, participants were assigned to different groups based on their tumor type.

BIOLOGICAL

BGB-A317

Participants were assigned to different groups based on their tumor types

Trial Locations (27)

704

National Cheng Kung University Hospital, Tainan City

1023

Auckland City Hospital, Grafton

2050

Chris O'Brien Lifehouse, Camperdown

3004

Nucleus Network, Melbourne

3080

Seoul National University Hospital, Seoul

3144

Cabrini Hospital, Malvern

3204

Waikato, Hamilton

4102

Princess Alexandra Hospital, Woolloongabba

4216

Tasman Oncology Research Ltd, Southport

5505

Asan Medical Center, Seoul

6022

Wellington Hospital, Wellington

11217

Taipei Veterans General Hospital, Taipei

13620

Seoul National University Bundang Hospital, Seongnam

33305

Linkou Chang Gung Memorial Hospital, Taoyuan District

61363

Chang Gung Memorial Hospital, Sachin, Taoyuan District

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

02114

Massachusetts General Hospital, Boston

77024-2545

Oncology Consultants, P.A., Houston

Unknown

Prince of Wales Hospital, Sydney

Royal Adelaide Hospital, Adelaide

The Queen Elizabeth Hospital, Woodville South

Monash Health, Clayton

Peter MacCallum Cancer Centre, East Melbourne

Austin Health Hospital, Heidelberg

Royal Melbourne Hospital, Melbourne

Linear Clinical Research/Sir Charles Gairdner Hospital, Nedlands

National Taiwan University Hospital, Taipei

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY