Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes

PHASE4CompletedINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

December 30, 2020

Study Completion Date

December 31, 2020

Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG

Saxagliptin

Take saxagliptin tablet 5mg p.o. qd. for 104 weeks after randomization.

DRUG

Vitamin D3

Take vitamin D drops 2000 IU p.o. qd. for 104 weeks after randomization.

DRUG

Insulin

For optimal control of patients' glucose, researchers can initiate insulin therapy at any time in this trial, choose any brands of insulin after discussion with the patient.

DRUG

Metformin

Take Metformin tablet 1.5g p.o. per day for 104 weeks (adjust the dose between 1-1.7g per day according to subject's specific situation) before or after randomization.

Trial Locations (39)

100044

Peking University People's Hospital, Beijing

100730

Beijing Hospital of the Ministry of Health, Beijing

110122

The First Hospital of China Medical University, Shenyang

130000

The Second Hospital of Jilin University, Changchun

130021

Jilin Province People's Hospital, Changchun

140400

Affiliated Heji Hospital of Changzhi Medical College, Changzhi

150081

Harbin Medical University, Harbin

200031

Shanghai Xuhui District Central Hospital, Shanghai

210029

Jiangsu Province Hospital, Nanjing

225001

The Northern Jiangsu People's Hospital, Yangzhou

266000

The Affiliated Hospital of Qingdao University, Qingdao

310009

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

325000

The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

330008

The Third Affiliated Hospital of Nanchang University, Nanchang

350005

Quanzhou First Hospital, Fujian, Quanzhou

The First Affiliated Hospital of Fujian Medical University, Fujian

400042

The First Affiliated Hospital of Chongqing Medical University, Chongqing

410011

Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha

414000

The First People's Hospital of Yueyang, Yueyang

415003

The First People's Hospital of Changde, Changde

418000

The First People's Hospital of Huaihua, Huaihua

421001

The First Affiliated Hospital of South China University, Hengyang

The Second Hospital University of South China, Hengyang

450003

Henan Provincial People's Hospital, Zhengzhou

471023

The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

510080

Guangdong General Hospital, Guangzhou

510120

Guangzhou First People's Hospital, Guangzhou

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

523059

Dongguan People's Hospital, Dongguan

530021

The First Affiliated Hospital of Guangxi Medical University, Nanning

570311

Hainan General Hospital, Haikou

650032

First People's Hospital of Yunnan Province, Kunming

710032

The First Affiliated Hospital of The Fourth Military Medical University, Xi’an

730000

Gansu Provincial Hospital, Lanzhou

063000

Tangshan Gongren Hospital063000, Tangshan

Tangshan Gongren Hospital, Tangshan

010050

The Affiliated Hospital of Inner Mongolia Medical University, Hohhot

046000

Heping Hospital of Changzhi Medical College, Changzhi

All Listed Sponsors
collaborator

Beijing Hospital

OTHER_GOV

collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

collaborator

First Affiliated Hospital of Chongqing Medical University

OTHER

collaborator

The First Affiliated Hospital of Henan University of Science and Technology

OTHER

lead

Second Xiangya Hospital of Central South University

OTHER

NCT02407899 - Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes | Biotech Hunter | Biotech Hunter