BNHL-2015 for Children or Adolescents in China

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

January 31, 2015

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2029

Conditions
Mature B-cell Non-Hodgkin Lymphoma
Interventions
DRUG

Prednisone,Vincristine, Cyclophosphamide

Prednisone 45mg/m2, D1\~7; Vincristine 1.5mg/m2(MAX 2mg), D1; Cyclophosphamide 300mg/m2, D1; Intrathecal injection, D1;

DRUG

Cyclophosphamide, Vincristine, Cytarabine, Doxorubincin, Prednisone

Cyclophosphamide 800mg/m2, D1, then 200mg/m2, D2\~4;Vincristine 1.5mg/m2 (MAX 2mg), D1; Cytarabine 1g/m2/dose, (2 doses, 12-hour interval), D4;Doxorubincin 20mg/m2, D2,3; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;

DRUG

Ifosphamide, Etoposide, Methotrexate, Vincristine, Prednisone

Ifosphamide 1.2g/m2, D1\~5; Etoposide, 60mg/m2, D3\~5; Methotrexate, 0.5g/m2, D1;Vincristine 1.5mg/m2 (MAX 2mg), D1; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1;

DRUG

Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone

Cyclophosphamide 800mg/m2, D1, then 200mg/m2, D2\~4;Vindelsine 3mg/m2 (MAX 5mg), D1; Cytarabine 2g/m2/dose, (2 doses, 12-hour interval), D4;Doxorubincin 20mg/m2, D2,3; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;

DRUG

Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone

Ifosphamide 1.2g/m2, D1\~5; Etoposide, 100mg/m2, D3\~5; Methotrexate, 5g/m2, D1;Vindelsine 3mg/m2 (MAX 5mg), D1; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;

DRUG

Rituximab

375mg/m2, 4 injections for patients in Risk group4; D0 of Protocol AA or BB;

Trial Locations (1)

Unknown

West China Second University Hospital of Sichuan University, Chengdu

All Listed Sponsors
collaborator

Tongji Hospital

OTHER

collaborator

Nanjing Children's Hospital

OTHER

collaborator

West China Second University Hospital

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Children's Hospital of Soochow University

OTHER

collaborator

Tianjin Medical University Cancer Institute and Hospital

OTHER

lead

Children's Cancer Group, China

NETWORK

NCT02405676 - BNHL-2015 for Children or Adolescents in China | Biotech Hunter | Biotech Hunter