Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis

NACompletedINTERVENTIONAL
Enrollment

139

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

November 23, 2020

Study Completion Date

February 15, 2021

Conditions
Clinical High Risk for Psychosis
Interventions
BEHAVIORAL

Targeted Cognitive Training

Targeted Cognitive Training is performed on the computer through Posit Science. Games are modern and engaging modifications of classic neuropsychological tests, such as set-shifting games modeled on the Wisconsin Card Sort Test, and cognitive control games modeled on Stroop-like interference tasks. Games will target two sets of skills: Targeted cognitive skills include: processing speed, memory, attention, flexibility/cognitive-control, and problem-solving. After 20 hours of training on these skills, participants will complete 20 hours of training on core social cognitive skills, including facial affect recognition, gaze direction perception, and face identity recognition, and theory of mind.

BEHAVIORAL

Computer Games

The comparison intervention consists of 40 hours of commercially available and cognitively non-specific computer games. These computer games - such as checkers, solitaire, crossword puzzles - are entertaining and engaging but do not target specific neurocognitive skills.

Trial Locations (1)

60612

Rush University Medical Center, Chicago

All Listed Sponsors
collaborator

Harvard Medical School (HMS and HSDM)

OTHER

collaborator

Beth Israel Deaconess Medical Center

OTHER

collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Rush University Medical Center

OTHER

NCT02404194 - Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis | Biotech Hunter | Biotech Hunter