A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

PHASE3CompletedINTERVENTIONAL
Enrollment

1,274

Participants

Timeline

Start Date

April 1, 2015

Primary Completion Date

January 19, 2024

Study Completion Date

April 10, 2024

Conditions
Stroke, Acute
Interventions
DRUG

Tenecteplase

TNK will be administered as a single intravenous bolus over 1-2 minutes within 90 minutes of the CT scan.

DRUG

Antiplatelet treatment

Low dose aspirin (single agent) will be the choice of most physicians, some Investigators will chose to use the combination of aspirin and clopidogrel.

Trial Locations (61)

Unknown

Calvary Public Hospital Bruce, Canberra

John Hunter Hospital, Newcastle

Gold Coast University Hospital, Gold Coast

Royal Adelaide Hospital, Adelaide

Box Hill Hospital, Box Hill

Royal Melbourne Hospital, Melbourne

Fiona Stanley Hospital, Murdoch

Medical University of Vienna (Coordinating Centre), Vienna

St. John's of God Hospital Vienna, Vienna

Hospital de Clínicas de Botucatu, Botucatu

Instituto Hospital de Base do Distrito Federal, Brasília

Hospital Universitário Maria Aparecida Pedrossian, Campo Grande

Hospital Celso Ramos Florianopolos, Celso Ramos

Hospital Geral de Fortaleza, Fortaleza

Clinica Neurologica e Neurocirurgica de Joinville Ltda, Joinville

Porto Alegre Hospital, Porto Alegre

Santa Casa de Porto Alegre, Porto Alegre

Hospital de Clínicas de Ribeirão Preto, Ribeirão Preto

Americas Medical City, Rio de Janeiro

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo

Hospital São Paulo UNIFESP, São Paulo

Irmandade Da Santa Casa de Misericordia de Sao Paulo, São Paulo

Hospital Estadual Central, Vitória

University of Alberta, Edmonton

Vancouver General Hospital, Vancouver

Victoria General Hospital, Victoria

Hamilton Health Sciences Centre, Hamilton

Kingston General Hospital, Kingston

London Health Sciences Centre, London

Ottawa General Hospital, Ottawa

St. Michael's Hospital, Toronto

Sunnybrook Health Sciences Centre, Toronto

Toronto Western, Toronto

McGill University, Montreal

CHU de Québec-Université Laval, Québec

University of Saskatchewan/ Royal University Hospital, Saskatoon

University Central Hospital HUCH, Helsinki

Beaumont Hospital, Dublin

Mater Misericordiae University Hospital Dublin, Dublin

Christchurch Hospital, Christchurch

National Neuroscience Institute Tan Tock Seng Hospital, Singapore

Singapore General Hospital, Singapore

Complejo Jospitalario Universitario A Coruna, A Coruña

Vall d'Hebron Institut de Recerca (VHIR), Barcelona

Vall d'Hebron Institut de Recerca, Barcelona

Hospital Universitari Doctor Josep Trueta, Girona

Clinc University Hospital Valladolid, Valladolid

Countess of Chester, London

St George's University Hospitals NHS Foundation trust, London

Stoke University of North Midlands, London

University College London Hospital, London

Royal Victoria Hospital, Belfast

Queen Elizabeth University Hospital, Glasgow

Queen Elizabeth Hospital, Birmingham

Addenbrooke Hospital, Cambridge

Charring Cross Hospital, London

Kings College Hospital, London

Nottingham University Hospital, Nottingham

John Radcliffe Hospital, Oxford

T2N 2T9

University of Calgary/Foothills Medical Centre, Calgary

V3L 3W7

Royal Columbian Hospital, New Westminster

All Listed Sponsors
lead

University of Calgary

OTHER

NCT02398656 - A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion | Biotech Hunter | Biotech Hunter