Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)

PHASE3CompletedINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

November 10, 2015

Primary Completion Date

July 17, 2019

Study Completion Date

November 21, 2022

Conditions
Leukemia, Acute Lymphoblastic
Interventions
DRUG

Blinatumomab

15 μg/m\^2/day as a continuous intravenous infusion (CIVI) for 4 weeks

DRUG

Dexamethasone

10 mg/m\^2/day intravenous (IV) on Days 1-6

DRUG

Vincrisitne

1.5 mg/m\^2/day IV on Days 1 and 6

DRUG

Daunorubicin

30 mg/m\^2 IV over 24 hours on Day 5

DRUG

Methotrexate

1 g/m\^2 IV over 36 hours on Day 1

DRUG

Ifosfamide

800 mg/m\^2 IV for 1 hour on Days 2-4

DRUG

PEG-asparaginase

1000 U/m\^2 IV for 2 hours or intramuscularly (IM) on Day 6

DRUG

Erwinia-asparaginase

In case of allergic reaction to PEG-asparaginase, participants could change to erwinia-asparaginase, 20,000 units/m2 every 48 hours for a total of 6 doses

Trial Locations (103)

1020

Research Site, Brussels

1090

Research Site, Vienna

1200

Research Site, Brussels

2031

Research Site, Randwick

2100

Research Site, København Ø

2145

Research Site, Westmead

3000

Research Site, Leuven

3052

Research Site, Parkville

4000

Research Site, Liège

4056

Research Site, Basel

4101

Research Site, South Brisbane

6020

Research Site, Innsbruck

8032

Research Site, Zurich

8036

Research Site, Graz

9000

Research Site, Ghent

10126

Research Site, Torino

11527

Research Site, Goudi

13353

Research Site, Berlin

13385

Research Site, Marseille

15706

Research Site, Santiago de Compostela

16147

Research Site, Genova

20246

Research Site, Hamburg

20900

Research Site, Monza (MB)

24105

Research Site, Kiel

27100

Research Site, Pavia

28009

Research Site, Madrid

28046

Research Site, Madrid

28660

Research Site, Boadilla del Monte

29011

Research Site, Málaga

30120

Research Site, El Palmar

30625

Research Site, Hanover

33076

Research Site, Bordeaux

34295

Research Site, Montpellier

35040

Research Site, Izmir

35128

Research Site, Padua

35392

Research Site, Giessen

38039

Research Site, Kayseri

39008

Research Site, Santander

40138

Research Site, Bologna

40225

Research Site, Düsseldorf

41013

Research Site, Seville

44093

Research Site, Nantes

44340

Research Site, Guadalajara

45122

Research Site, Essen

46026

Research Site, Valencia

48149

Research Site, Münster

54511

Research Site, Vandœuvre-lès-Nancy

59037

Research Site, Lille

60590

Research Site, Frankfurt am Main

64460

Research Site, Monterrey

67200

Research Site, Strasbourg

69008

Research Site, Lyon

72076

Research Site, Tübingen

75012

Research Site, Paris

75019

Research Site, Paris

79106

Research Site, Freiburg im Breisgau

80123

Research Site, Napoli

80337

Research Site, München

89075

Research Site, Ulm

91054

Research Site, Erlangen

97080

Research Site, Würzburg

115478

Research Site, Moscow

197022

Research Site, Saint Petersburg

400177

Research Site, Cluj-Napoca

3109601

Research Site, Haifa

4920235

Research Site, Petah Tikva

5262000

Research Site, Tel Litwinsky

6423906

Research Site, Tel Aviv

9112001

Research Site, Jerusalem

C1199ABB

Research Site, Ciudad Autonoma de Buenos Aires

81520-060

Research Site, Curitba

90035-903

Research Site, Porto Alegre

04039-001

Research Site, São Paulo

08270-070

Research Site, São Paulo

150 06

Research Site, Prague

07740

Research Site, Jena

00161

Research Site, Roma

00165

Research Site, Roma

01120

Research Site, Mexico City

3015 CN

Research Site, Rotterdam

3584 CS

Research Site, Utrecht

0372

Research Site, Oslo

85-094

Research Site, Bydgoszcz

30-663

Research Site, Krakow

20-093

Research Site, Lublin

50-556

Research Site, Wroclaw

41-800

Research Site, Zabrze

1099-023

Research Site, Lisbon

4200-072

Research Site, Porto

022328

Research Site, Bucharest

08035

Research Site, Barcelona

08041

Research Site, Barcelona

171 76

Research Site, Stockholm

01130

Research Site, Adana

07059

Research Site, Antalya

B4 6NH

Research Site, Birmingham

BS2 8BJ

Research Site, Bristol

G51 4TF

Research Site, Glasgow

WC1N 3JH

Research Site, London

M13 9WL

Research Site, Manchester

NE1 4LP

Research Site, Newcastle upon Tyne

S10 2TH

Research Site, Sheffield

SM2 5PT

Research Site, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT02393859 - Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL) | Biotech Hunter | Biotech Hunter