Comparison of Topical Versus Intravenous Tranexamic Acid in TKA

PHASE3CompletedINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

May 31, 2015

Study Completion Date

October 31, 2015

Conditions
Total Blood Loss
Interventions
DRUG

normal saline

The normal saline solution will be prepared under sterile conditions. In the operation room the sterile bag containing the solution will be given to the scrub nurse. The contents (60 ml) will be emptied in a sterile surgical bowl and the nurse will ask the surgeon to apply the solution before wound closure.The dosage and applying route can also be looked up in doctor's order sheet.

DRUG

Tranexamic Acid

The Tranexamic Acid solution will be prepared under sterile conditions. In the operation room the sterile bag containing the solution will be given to the scrub nurse. The contents (60 ml) will be emptied in a sterile surgical bowl and the nurse will ask the surgeon to apply the solution before wound closure.The dosage and applying route can also be looked up in doctor's order sheet.

DRUG

Tranexamic Acid

The Tranexamic Acid solution will be prepared under sterile conditions. In the operation room the sterile bag containing the solution will be given to the circuit nurse and the circuit nurse will ask the anesthetist to apply the solution intravenously before tourniquet deflation. The dosage and applying route can also be looked up in doctor's order sheet.

Trial Locations (1)

200001

Orthopedic Department of Ruijin hospital, Shanghai

All Listed Sponsors
lead

Shanghai Jiao Tong University School of Medicine

OTHER

NCT02393300 - Comparison of Topical Versus Intravenous Tranexamic Acid in TKA | Biotech Hunter | Biotech Hunter