Effects of Bronchial Segmental Endotoxin Instillation in Humans

PHASE2Enrolling by invitationINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

June 18, 2015

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Acute Lung Inflammation
Interventions
OTHER

Saline

Investigate the changes in miRNA signatures found in BAL and lung cells from healthy volunteers at baseline and at 6 hours after 1800 of normal Saline installed in six 30 mL aliquots into the left (lingual) and right (middle lobe) lung segments (360 mL total).

BIOLOGICAL

Endotoxin

Investigate the changes in miRNA signatures found in BAL and lung cells from healthy volunteers at baseline and at 6, 24, or 48 hours after endotoxin segmental lung challenge.

Trial Locations (1)

20892

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
lead

National Institutes of Health Clinical Center (CC)

NIH

NCT02392442 - Effects of Bronchial Segmental Endotoxin Instillation in Humans | Biotech Hunter | Biotech Hunter