A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

163

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

October 25, 2024

Study Completion Date

March 11, 2026

Conditions
Ewing SarcomasChondrosarcomasOsteosarcomasChondromaCIC-Rearranged Sarcoma
Interventions
DRUG

Regorafenib

For adults patients and children with BSA ≥1.70 m² : 4 tablets once daily until progression or unacceptable toxicity For children with BSA ≥1.30 and ≤1.69 m² : 3 tablets once daily until progression or unacceptable toxicity

DRUG

Placebo

For adults patients and children with BSA ≥1.70 m² : 4 tablets once daily and switch to regorafenib after confirmed progression For children with BSA ≥1.30 and ≤1.69 m² : 3 tablets once daily and switch to regorafenib after confirmed progression

Trial Locations (19)

13273

Institut Paoli Calmettes, Marseille

13385

La Timone University Hospital, Marseille

14176

Centre Francois Baclesse, Caen

21079

Centre Georges Francois Leclerc, Dijon

25030

Hopital Jean Monjoz, Besançon

31052

Institut Claudius Regaud, Toulouse

33076

Institut Bergonie, Bordeaux

34298

ICM Val d'Aurelle, Montpellier

35042

Centre Eugene Marquis, Rennes

37000

CHU Bretonneau, Tours

42270

Institut de Cancérologie Lucien Neuwirth (ICLN), Saint-Priest-en-Jarez

44805

Institut de cancerologie de l'ouest site Rene Gauducheau, Saint-Herblain

54519

Institut de cancerologie de lorraine alexis Vautrin, Vandœuvre-lès-Nancy

59020

Centre Oscar Lambret, Lille

69373

Centre Léon Berard, Lyon

75014

Hôpital Cochin, Paris

94800

Gustave Roussy, Villejuif

06189

Centre Antoine Lacassagne, Nice

Unknown

Institut Curie, Paris

All Listed Sponsors
lead

UNICANCER

OTHER