A Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan

"S-1: Administered orally twice daily from day 1 for 7 consecutive days followed by a 7-day recovery period in a 14-day cycle.~The starting dose of S-1 will be two levels below the recommended dose defined in SIRI (20 mg/m² BID minimum) with a cohort dose escalation by 5 mg/m² increments (5 dose levels)."

Irinotecan : fixed dose of 180 mg/m² IV over 90 minutes on d1 of every cycle

Oxaliplatin : fixed dose of 85 mg/m² over 120 minutes on d1 of every cycle

G-csf : d8 to d13 systematically