NCT02370745 - Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

November 30, 2014

Primary Completion Date

March 31, 2018

Study Completion Date

March 31, 2018

Conditions

Sarcopenia

Interventions

DRUG

GLP-1

GLP-1 effects on skeletal muscle glucose and amino acid metabolism and microvascular blood flow will be scrutinised under the specified insulin concentrations. It will also be used to test the effect of intravenous feed on insulin secretion.

DRUG

Insulin Actrapid

Skeletal muscle metabolic and microvascular parameters will be tested under specified insulin concentrations with or without GLP-1

DIETARY_SUPPLEMENT

Oral amino acids

Oral amino acids containing 15 g of amino acids

DRUG

GIP

This will be co infused with GLP-1 and intravenous amino acids

DRUG

Intravenous amino acids

This will aim to deliver iso equivalent amount to the amino acids administered orally

Trial Locations (1)

DE22 3DT

Division of Medical Sciences and Graduate Entry Medicine - School of Medicine - University of Nottingham, Derby

All Listed Sponsors

lead

University of Nottingham

OTHER