723
Participants
Start Date
April 16, 2015
Primary Completion Date
March 15, 2018
Study Completion Date
January 18, 2021
Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody
"Atezolizumab was administered as IV infusion at a dose of 1200 milligrams (mg) on Day 1 of each 21-day cycle. Atezolizumab was administered to participants who were randomized to Arm A (Atezolizumab + Nab-Paclitaxel + Carboplatin) and to participants in Arm B (Nab-Paclitaxel + Carboplatin) who cross over at progression."
Carboplatin
Carboplatin was administered at area under the concentration curve (AUC) 6 milligrams per milliliter per minute (mg/mL/min) on Day 1 of each 21-day cycle.
Nab-Paclitaxel
Nab-paclitaxel was administered as IV infusion at a dose of 100 milligrams per square meter (mg/m\^2) on Days 1, 8, and 15 of each 21-day cycle.
Pemetrexed
Switch maintenance to pemetrexed can be administered within 6 weeks of Day 1 of the last induction cycle.
Cliniques Universitaires St-Luc, Brussels
GasthuisZusters Antwerpen, Wilrijk
CHU Ambroise Paré, Mons
Werken Glorieux VZW, Ronse
Hospital de San Pedro de Alcantara, Cáceres
Laura and ISAAC Perlmutter Cancer Center at NYU Langone., New York
Clinical Research Alliance, Westbury
Consorcio Hospitalario Provincial de Castellon, Castellon de LA Plana/castello de LA Plana
Fondation Hopital Saint Joseph;Cardiologie Clinique, Marseille
Charite - Universitätsmedizin Berlin; Klinik fur Infektiologie und Pneumologie, Berlin
Complejo Hospitalario Universitario A Coruña, A Coruña
Pinnacle Health, Harrisburg
Lancaster General Hospital, Lancaster
Hospital Universitario Virgen de Las Nieves, Granada
Hospital General Universitario de Guadalajara, Guadalajara
Walter Reed National Military Medical Center, Bethesda
Center For Cancer and Blood Disorders, Bethesda
Galilee Medical Center, Nahariya
Complejo Hospitalario de Jaen, Jaén
Universitatsklinikum Schleswig-Holstein; Klinik fuer Innere Medizin I, Lübeck
Malteser Krankenhaus St. Franziskus-Hospital, Flensburg
Duke University Medical Center; Department of Medicine, Durham
Presbyterian Hospital, Charlotte
Hospital Universitario de Torrejon, Torrejón de Ardoz
Suburban Hematology / Oncology Associates, Lawrenceville
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Carrollton
Southeastern Regional Medical Center, Inc., Newnan
University Cancer & Blood Center, LLC; Research, Athens
Medizinische Hochschule Hannover, Hanover
Johannes Wesling Klinikum Minden, Minden
Florida Hospital, Orlando
Polyclinique Bordeaux Nord Aquitaine, Bordeaux
SCRI Florida Cancer Specialists East, West Palm Beach
Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building), St. Petersburg
SCRI Florida Cancer Specialists South, Fort Myers
Clinique Clementville; Hopital De Jour, Montpellier
Klinikum Kassel; Hautklinik, Kassel
Fachklinik für Lungenerkrankungen, Immenhausen
Hopital Pontchaillou, Rennes
University Oncology Associates, Chattanooga
SCRI Tennessee Oncology Chattanooga, Chattanooga
Hospital Universitario de Canarias, S. Cristobal de La Laguna
Hematology and Oncology Associates at Bridgepoint, Tupelo
Helios Klinik Wuppertal, Wuppertal
Praxis fur Haematologie und Internistische Onkologie, Velbert
Mark H. Zangmeister Center, Columbus
Clinique Catherine de Sienne, Nantes
HOPITAL DE LA SOURCE; Service de Cardiologie, Point Jaune, Orléans
Oncology Hematology Care, Inc., Hamilton
The Christ Hospital, Cincinnati
Hospital General Universitario de Valencia, Valencia
Hospital NisA 9 de Octubre, Valencia
Fort Wayne Med Oncology & Hematology Inc, Fort Wayne
Rabin Medical Center, Petach Tiqwa
Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza
St. Antonius Hospital, Eschweiler
Centre D'oncologie de Gentilly; Service Oncologie Medicale, Nancy
CHRU Nancy; Pneumologie, Vandœuvre-lès-Nancy
Mayo Clinic, Rochester
Katholisches Klinikum Marienhof, Koblenz Am Rhein
Joliet Oncology-Hematology; Associates, Ltd., Joliet
Krankenhaus Nordwest, Frankfurt am Main
University of Illinois at Chicago, Chicago
Illinois Cancer Care, Peoria
Ospedale Di Macerata; Oncologia, Macerata
Quincy Medical Group, Quincy
Southern Illinois University, Simmons Cancer Institute, Springfield
Ospedale Clinicizzato SS Annunziata, Chieti
Klinikum Mannheim GmbH Universitätsklinikum, Mannheim
Southeast Nebraska Cancer Ctr, Lincoln
Thoraxklinik Heidelberg gGmbH, Heidelberg
Assaf Harofeh Medical Center, Beer Yaakov
Robert Bosch Krankenhaus; Pneumologie und pneumologische Onkologie, Gerlingen
Universitätsklinikum Tübingen, Tübingen
Highlands Oncology Group, Springdale
Klinikum Esslingen GmbH; Frauenklinik, Esslingen am Neckar
St. Vincentius Kliniken Karlsruhe, Karlsruhe
SCRI The Center For Cancer and Blood Disorders, Denton
University of Texas M.D. Anderson Cancer Center, Houston
Schwarzwald-Baar Klinikum/VS GmbH; Onkologie/Hämatologie/Infektologie, Villingen-Schwenningen
Cancer Care Network of South Texas - SAT & BC, San Antonio
Azienda Osp Uni Seconda Università Degli Studi Di Napoli; Unità Operativa Oncologia Medica, Napoli
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli
LMU Klinikum der Universitat Munchen, München
Asklepios Fachkliniken GmbH, Gauting
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati, Avellino
Banner MD Anderson Cancer Center, Greeley
Va Sierra Nevada Health Care System, Reno
Hopital American de Paris (American Hospital of Paris), Neuilly-sur-Seine
Institut Hospitalier Franco-Britannique; Cancerologie, Levallois-Perret
Kaiser Permanente - South San Francisco, South San Francisco
Kaiser Permanente - San Francisco Medical Center, San Francisco
Hopital d'Instruction des Armees de Begin, Saint-Mandé
Kaiser Permanente - San Leandro Medical Center, San Leandro
Kaiser Permanente; Oncology Clinical Trials, Vallejo
Kaiser Permanente - Walnut Creek, Walnut Creek
Kaiser Permanente Oakland Medical Center, Oakland
Kaiser Permanente - Santa Clara, Santa Clara
Kaiser Permanente - San Jose Medical Center, San Jose
Kaiser Permanente Medical Center - Roseville, Roseville
Kaiser Permanente - Sacramento Medical Center and Medical Offices, Sacramento
Bezirksklinikum Obermain, Ebensfeld
Centre Hospitalier Regional Sud Reunion; Service de Pneumologie, Saint-Pierre
Helios Klinikum Erfurt, Erfurt
Rambam Health Corporation; Oncology Institute, Rambam
Meir Medical Center; Oncology, Kfar Saba
Chaim Sheba Medical Center, Ramat Gan
Tel Aviv Sourasky Medical Ctr; Oncology, Tel Aviv
Kaplan Medical Center, Rehovot
Soroka University Medical Centre, Beersheba
Hadassah Ein Karem Hospital; Oncology Dept, Jerusalem
Eastern Connecticut Hematology and Oncology Associates; (ECHO), Norwich
University of Miami School of Medicine - Sylvester at Deerfield, Deerfield Beach
University of Iowa Hospitals and Clinics, Iowa City
Lahey Clinic Med Ctr, Lexington
Southcoast Health System, Fairhaven
Englewood Hospital and Medical Center, Englewood
Saint Barnabas Medical Center, Livingston
Cancer Inst. of New Jersey, New Brunswick
W.G. Bill Hefner VA Medical Center, Salisbury
Rhode Island Hospital, Providence
Greenville Health System; Cancer Center, Greenville
BC Cancer - Surrey, Surrey
Royal Victoria Regional Health Centre, Barrie
William Osler Health Centre, Etobicoke
Cite de La Sante de Laval; Hemato-Oncologie, Laval
Hôpital Maisonneuve - Rosemont, Montreal
Klinikum Chemnitz gGmbH, Chemnitz
SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera
Ospedale Santa Maria Della; Misericordia Di Perugia; Farmacia Ospedaliera, Perugia
Hospital Son Llatzer, Palma de Mallorca
Hospital Santa Creu i Sant Pau, Barcelona
Hoffmann-La Roche
INDUSTRY