A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients

PHASE1CompletedINTERVENTIONAL
Enrollment

73

Participants

Timeline

Start Date

April 28, 2015

Primary Completion Date

January 29, 2020

Study Completion Date

March 7, 2022

Conditions
Myelodysplastic SyndromeAcute Myeloid LeukemiaChronic Myelomonocytic Leukemia
Interventions
DRUG

PF-04449913 (Glasdegib)

Daily dose of PF-04449913 100mg tablet in a continuous regimen of 28 day cycles

DRUG

Azacitidine

75mg/m2 on Days 1-7 (+/- 3 days for each dose) of a 28 day cycle

Trial Locations (33)

2060

Ziekenhuis Netwerk Antwerpen - Campus Stuivenberg, Antwerp

3000

UZ Leuven, Leuven

10461

Montefiore Einstein Center for Cancer, The Bronx

10467

Montefiore Medical Center, The Bronx

11794

Stony Brook University Hospital Cancer Center, Stony Brook

Stony Brook University, Stony Brook

14263

Roswell Park Cancer Institute, Buffalo

21287

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

27705

Duke University Health System: Adult Bone Marrow Transplant Clinic, Durham

27710

Duke University Health System, Duke University Hospital, Durham

Duke University Health System, Durham

Investigational Chemotherapy Service, Durham

35233

University of Alabama at Birmingham the Kirklin Clinic, Birmingham

35249

University of Alabama at Birmingham, Birmingham

37044

CHU de Tours-Hopital Bretonneau-Centre Regional de cancerologie Henry Kaplan, Tours

37232

Henry-Joyce Cancer Center, Nashville

Vanderbilt - Ingram Cancer Center, Nashville

38114

Staedtisches Klinikum Braunschweig gGmbH, Braunschweig

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

69495

Hospices Civils de Lyon - Hopital Lyon Sud- Hematologie, Pierre-Bénite

75475

Hopital Saint-Louis (AP-HP) - Service Hematologie Senior, Paris

80054

CHU d'Amiens-Picardie - Hopital SUD, Amiens

84112

Huntsman Cancer Hospital, Salt Lake City

Huntsman Cancer Institute, Salt Lake City

92093

UC San Diego Moores Cancer Center, La Jolla

98109

Seattle Cancer Care Alliance (SCCA), Seattle

98195

University of Washington Medical Center (UWMC), Seattle

T6G 2B7

University Of Alberta Hospital, Edmonton

06510

Smilow Cancer Center at Yale New Haven Hospital, New Haven

T2N 4N2

Tom Baker Cancer Center, Calgary

SE5 9RS

King's College Hospital, London

NE7 7DN

The Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne

OX3 9DU

Oxford University Hospitals NHS Foundation Trust, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY