50
Participants
Start Date
June 27, 2012
Primary Completion Date
June 24, 2015
Study Completion Date
March 27, 2019
Fresh Frozen Plasma
An INR dose-response curve with associated transfusion algorithm was generated for plasma in bleeding patients with chronic liver disease. In the intervention arm we will determine the plasma transfusion dose using the algorithm dosing table based on the pre-transfusion INR and the clinician chosen INR target. In the usual care group the dosing will be determined by the clinician.
Pre-Transfusion International Normalized Ratio (INR)
INR result prior to Fresh Frozen Plasma (FFP) transfusion determined by clinical lab testing performed within 6 hours to 1 day before transfusion start time.
Post-Transfusion International Normalized Ratio (INR)
INR result after Fresh Frozen Plasma (FFP) transfusion completed, determined by clinical lab testing performed within 1 hour after transfusion completed.
University of Colorado Hospital, Aurora
University of Colorado, Denver
OTHER