A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,202

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

September 13, 2019

Study Completion Date

December 7, 2020

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody

Atezolizumab was administered as IV infusion at a dose of 1200 milligrams (mg) on Day 1 of each 21-day cycle until loss of clinical benefit.

DRUG

Bevacizumab

Bevacizumab was administered as IV infusion at a dose of 15 milligrams per kilogram (mg/kg) on Day 1 of each 21-day cycle until progressive disease, unacceptable toxicity, or death.

DRUG

Carboplatin

Carboplatin was administered at area under the concentration-time curve (AUC) 6 milligrams per milliliter per minute (mg/mL/min) on Day 1 of each 21-day cycle for 4 or 6 cycles or until loss of clinical benefit whichever occurs first.

DRUG

Paclitaxel

Paclitaxel was administered as IV infusion at a dose of 200 milligrams per square meter (mg/m\^2) on Day 1 of each 21-day cycle for 4 or 6 cycles or until loss of clinical benefit whichever occurs first.

Trial Locations (240)

0

Clinica Santa Maria, Santiago

112

Cheng Hsin General Hospital, Taipei

333

Chang Gung Medical Foundation Linkou Branch, Taoyuan

500

Changhua Christian Hospital; Hematology-Oncology, Changhua

613

Chang Gung Memorial Hospital Chiayi, Putzu

736

Chi Mei Medical Center Liou Ying Campus, Liuying Township

807

Kaohsiung Medical University Hospital; Department of Urology, Kaohsiung City

1019

Centro Medico Austral, Buenos Aires

1303

MHAT Serdika, EOOD, Sofia

2000

Hospital Provincial del Centenario, Rosario

2050

Chris O'Brien Lifehouse, Camperdown

2100

CH de Saint Quentin, Saint-Quentin

2139

Concord Repatriation General Hospital, Concord

2747

Nepean Cancer Care Centre, Sydney

3021

Sunshine Hospital, St Albans

3084

Austin Health, Heidelberg

3144

Cabrini Hospital Malvern, Malvern

3181

The Alfred Hospital, Prahan

3199

Frankston Hospital, Frankston

4000

CHU de Liège, Liège

Multiprofile Hospital for Active Treatment Central Onco Hospital OOD, Plovdiv

4032

Prince Charles Hospital; Department of Medical Oncology, Chermside

4101

Kantonsspital Baselland, Bruderholz

4102

Princess Alexandra Hospital, Woolloongabba

4200

Hospital de Sao Joao; Servico de Pneumologia, Porto

4600

Klinikum Wels-Grieskirchen, Wels

4810

Townsville Hospital, Townsville

5000

Royal Adelaide Hospital, Adelaide

Clinique Ste-Elisabeth, Namur

5020

Paracelsus Medizinische Privatuniversität, Salzburg

5037

Adelaide Cancer Centre, Kurralta Park

6000

Luzerner Kantonsspital Sursee, Lucerne

6009

Sir Charles Gairdner Hospital, Nedlands

6300

Fundacion Koriza, Santa Rosa

7000

Royal Hobart Hospital, Hobart

7250

Launceston General Hospital, Launceston

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

9007

Kantonsspital St. Gallen; Onkologie/Hämatologie, Sankt Gallen

10041

National Taiwan Uni Hospital, Taipei

10467

Montefiore Medical Center, The Bronx

11219

Maimonides Medical Center, Brooklyn

11490

Tri-Service General Hospital, Taipei

13008

Hôpital Saint Joseph, Marseille

13015

Hopital Nord AP-HM, Marseille

14004

Hospital Universitario Reina Sofia, Córdoba

14165

Helios Klinikum Emil von Behring GmbH, Berlin

15212

Allegheny Cancer Center, Pittsburgh

15232

Univ of Pittsburgh Medical Ctr, Pittsburgh

16132

Istituto Nazionale per la Ricerca sul Cancro di Genova, Genoa

16147

ASL 3 Genovese; DSM, Genoa

18015

St. Luke's Cancer Care Associates, Bethlehem

20817

Regional Cancer Care Associates, Bethesda

21029

Communal Nonprofit Enterprise Podilsky Regional Center Of Oncology OfTheVinnytsia Regional Council, Vinnytsia

21044

Maryland Oncology Hematology, P.A., Columbia

21075

Asklepios Klinik Harburg, Hamburg

21202

Mercy Medical Center, Baltimore

22031

Virginia Cancer Specialists, PC, Fairfax

22927

LungenClinic Großhansdorf GmbH, Großhansdorf

23226

Virginia Cancer Institute, Richmond

23502

Virginia Oncology Associates, Norfolk

24014

Blue Ridge Cancer Care, Roanoke

26506

West Virginia University; Mary Babb Randolph Can Ctr, Morgantown

27003

Hospital Lucus Augusti; Servicio de Oncologia, Lugo

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28034

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid

28040

Hospital Clinico San Carlos; Servicio de Oncologia, Madrid

Hospital Universitario Fundación Jimenez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28050

Hospital Universitario HM Sanchinarro-CIOCC, Madrid

28100

A.O.U. Maggiore della Carità, Novara

28374

First Health of the Carolinas, Pinehurst

30318

Piedmont Cancer Institute, PC, Atlanta

31059

Hôpital Larrey;Université Paul Sabatier, Toulouse

32005

Complejo Hospitalario U. de Ourense, Ourense

32258

Cancer Specialists of North Florida - Baptist South, Jacksonville

33076

Institut Bergonié Centre Régional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest, Bordeaux

33140

Mount Sinai Medical Center, Miami Beach

33308

Holy Cross Hospital Inc, Fort Lauderdale

33600

CHU de Bordeaux, Pessac

33611

Ev.Krankenhaus Bielefeld gGmbH; Klinik für Innere Medizin und Geriatrie, Bielefeld

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

35016

Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria

36011

Poltava Regional Clinical Oncology Dispensary of Poltava Regional Council; Thoracic department, Poltava

37920

Tennessee Cancer Specialists, Knoxville

38043

CHU de Grenoble, Grenoble

38138

West Clinic, Germantown

39008

Hospital Universitario Marques de Valdecilla, Santander

40005

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary, Sumy

40202

Norton Cancer Institute, Louisville

40705

Taichung Veterans General Hospital, Xitun Dist.

43623

Mercy St Anne Hospital, Toledo

44791

Augusta Kranken-Anstalt gGmbH, Bochum

46010

Hospital Clinico Universitario de Valencia, Valencia

46800

Hospital Lluis Alcanyis De Xativa, Xàtiva

48106

St. Joseph Mercy Health System, Ann Arbor

48431

Stiftung Mathias-Spital Rheine, Rheine

49102

Municipal Institution City Clinical Hospital #4 of Dnipro City Council - PPDS; Dept of Chemotherapy, Dnipropetrovsk

50048

ME Kryviy Rih Oncology Dispensary of Dnipropetrovs'k Regional Council; Chemotherapy Department, Kryvyi Rih

50080

Centro Hemato Oncologico Privado; Oncologia, Toluca

51109

Kliniken der Stadt Koln gGmbH; Lungenklinik Onkologische Ambulanz, Cologne

52722

Hematology-Oncology; Associates of the Quad Cities, Bettendorf

55043

Ospedale Versilia, Lido di Camaiore

55426

Park Nicolett - Frauenshuh Cancer Center, Saint Louis Park

55805

St. Luke's Regional Cancer Center, Duluth

57124

Ospedale Civile - Livorno, Livorno

58013

ME Bukovinian Clinical Oncology Center, Chernivtsi

58675

Lungenklinik Hemer, Hemer

59102

Billings Clinic, Billings

59802

Montana Cancer Specialists, Missoula

60068

Oncology Specialists, S.C., Park Ridge

60426

Ingalls Memorial Hospital, Harvey

60487

St. Elisabethen Krankenhaus, Frankfurt am Main

60612

Rush University Medical Center, Chicago

60637

Univ of Chicago, Chicago

61024

SI Institute of Medical Radiology n.a. S.P. Hryhoriev of NAMS of Ukraine, Kharkiv

61070

Communal Non profit Enterprise Regional Center of Oncology; Oncosurgical dept of thoracic organs, Kharkiv

63131

Missouri Baptist Medical Center, St Louis

64020

Centro Universitario Contra El Cancer, Monterrey

64111

St. Luke's Cancer Institute, Kansas City

66421

Universität Des Saarlandes; Klinik für Innere Medizin V, Homburg

69040

MNPE Zaporizhzhia Regional Antitumor Center ZRC, Zaporizhzhia

72015

Centre Jean Bernard Clinique Victor Hugo, Le Mans

74245

Klinik Loewenstein gGmbH; Onk & Pal, Löwenstein

75601

Longview Cancer Center, Longview

75908

Hôpital Européen Georges Pompidou, Paris

76018

Municipal Institution SubCarpathian Clinical Oncological Centre; Surgical department#2, Ivano-Frankivsk

76090

Cancerologia de Queretaro, Querétaro

77030

Houston Methodist Cancer Center, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

80124

Kaiser Permanente, Lonetree

80131

AORN A Cardarelli, Napoli

80218

Rocky Mountain Cancer Center, Denver

81925

Klinikum Bogenhausen, München

83000

Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer, Toulon

Hôpital d'Instruction des Armées de Sainte Anne; Service de Pneumologie, Toulon

85224

Ironwood Cancer & Research Centers, Chandler

86001

Arizona Oncology Associates, Flagstaff

86156

Zentralklinikum Augsburg, Augsburg

88000

Uzhgorod Central City Clinical Hospital, Uzhhorod

88014

MNPE Transcarpathian Antitumor Center of the Transcarpathian Regional Council; Chemotherapy Dept, Uzhhorod

89014

Comprehensive Cancer Centers of Nevada, Henderson

92037

Scripps Health, La Jolla

92868

Chao Family Comprehensive Cancer Center UCI, Orange

93049

Krankenhaus Barmherzige Bruder Regensburg, Regensburg

93053

Klinikum der Universität Regensburg, Regensburg

94904

Marin Cancer Care Inc, Greenbrae

95123

Policlinico Vittorio Emanuele, Catania

97405

Service de Pneumologie Centre Hospitalier Régional La Réunion Site Felix Guyon, Saint-Denis

97477

Willamette Valley Cancer Insitute and Research Center, Springfield

97701

Bend Memorial Clinic, Bend

St. Charles Medical Center Bend; Cancer Care Of The Cascades, Bend

98101

Virginia Mason Medical Center, Seattle

98201

Providence Regional Cancer Partnership, Everett

99208

Medical Oncology Associates, Spokane

115478

Russian Oncology Research Center n.a. N.N. Blokhin, Moscow

143423

Moscow City Oncology Hospital #62, Moscovskaya Oblast

169610

National Cancer Centre; Medical Oncology, Singapore

196603

Evromedservis LCC, Pushkin

197022

City Clinical Oncology Dispensary, Saint Petersburg

280146

Hospital Universitario La Paz, Madrid

644013

Clinical Oncology Dispensary, Omsk

4810469

Sociedad de Investigaciones Medicas Ltda (SIM), Temuco

7500006

Health & Care SPA, Santiago

59040150

Liga Norte Riograndense Contra O Câncer, Natal

Unknown

Southern CA Permanente Med Grp, Bellflower

Centro Especializado de Enfermedades Neoplásicas, Arequipa

06810

Danbury Hospital, Danbury

06520

Yale Cancer Center, New Haven

04074

New England Cancer Specialists, Scarborough

07922

Summit Medical Group, Berkeley Heights

07652

Valley Hospital; Oncology Research, Paramus

08080

Regional Cancer Care Associates LLC, Sewell

45203-0542

University of Cincinnati, Cincinnati

98002-4117

MultiCare Regional Cancer Center - Auburn, Auburn

C1125ABD

Fundación CENIT para la Investigación en Neurociencias, Buenos Aires

X5000JHQ

Sanatorio Allende, Córdoba

F5300COE

Centro Oncologico Riojano Integral (CORI), La Rioja

R8500ACE

Centro de Investigacion; Clinica - Clinica Viedma S.A., Viedma

38082-049

CETUS Hospital Dia Oncologia, Uberaba

86 015 520

Instituto Do Cancer Delondrina_X; Unidade De Pesquisa Clinica, Londrina

95070-560

IPCEM; Instituto de Pesquisa de Estudos Multicêntricos, Caxias do Sul

90470-340

Hospital Mae de Deus, Porto Alegre

14784-400

Hospital de Cancer de Barretos, Barretos

14015-130

Instituto Ribeirãopretano de Combate Ao Câncer; Centro Especializado De Oncologia, Ribeirão Preto

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01509-010

Hospital A. C. Camargo; Oncologia, São Paulo

L1J 2J2

Lakeridge Health Center, Oshawa

01307

"Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden", Dresden

06120

Krankenhaus Martha-Maria; Halle-Dolau gGmbH, Halle

00128

Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica, Rome

00152

Azienda Ospedaliera San Camillo Forlanini, Rome

00168

Università Cattolica Del S Cuore, Rome

07100

Azienda Unita Sanitaria Locale N1 Sassari; Unita Operativa Di Oncologia Medica, Sassari

791-0280

National Hospital Organization Shikoku Cancer Center, Ehime

810-8563

National Hospital Organization Kyushu Medical Center, Fukuoka

811-1395

NHO Kyushu Cancer Center, Fukuoka

830-0011

Kurume University Hospital, Fukuoka

236-0051

Kanagawa Cardiovascular and Respiratory Center, Kanagawa

252-0375

Kitasato University Hospital, Kanagawa

606-8507

Kyoto University Hospital, Kyoto

981-1293

Miyagi Cancer Center, Miyagi

951-8566

Niigata Cancer Center Hospital, Niigata

545-8586

Osaka City University Hospital, Osaka

560-8552

National Hospital Organization Osaka Toneyama Medical Center, Osaka

105-8470

Toranomon Hospital, Tokyo

162-0052

Center Hospital of the National Center for Global Health and Medicine, Tokyo

181-8611

Kyorin University Hospital, Tokyo

641-8510

Wakayama Medical University Hospital, Wakayama

LV-1002

Pauls Stradins Clinical University Hospital, Riga

LV-1079

Riga East Clinical University Hospital Latvian Oncology Centre, Riga

08660

National Cancer Institute, Vilnius

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

1081 HV

Amsterdam UMC Location VUMC, Amsterdam

4818 CK

Amphia Ziekenhuis; Afdeling Longziekten, Breda

6716 RP

Ziekenhuis Gelderse Vallei, Ede

1201 DA

Tergooiziekenhuizen, Hilversum

2134 TM

Spaarne Gasthuis; Spaarne Ziekenhuis, Hoofddorp

6229 HX

Maastricht University Medical Center, Maastricht

3435 CM

St. Antonius Ziekenhuis; R&D Long, Nieuwegein

3015 GD

Erasmus MC; Afdeling Longziekten, Rotterdam

3079 DZ

Maasstad ziekenhuis, Rotterdam

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

7207 AE

Gelre Ziekenhuizen, Zutphen, Zutphen

04001

Centro Medico Monte Carmelo, Arequipa

Lima 34

Instituto Nacional de Enfermedades Neoplasicas, Lima

3000-602

Centro Hospitalar E Universitário de Coimbra EPE, Coimbra

1099-023

Instituto Portugues Oncologia de Lisboa Francisco Gentil EPE, Lisbon

1796-001

Hospital Pulido Valente; Servico de Pneumologia, Lisbon

4099-001

Centro Hospitalar do Porto - Hospital de Santo António, Porto

4200-072

Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe, Porto

813 69

Univerzitna nemocnica Bratislava, Bratislava

833 10

Narodny onkologicky ustav, Bratislava

058 01

POKO Poprad s.r.o., Poprad

07014

Hospital Universitario Son Espases, Palma de Mallorca

08908

Instituto Catalan de Oncologia de Hospitalet (ICO); Servicio de Farmacia, L'Hospitalet de Llobregat

08003

Hospital del Mar, Barcelona

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

00704

National Cheng Kung Univ Hosp, Tainan City

03115

Kyiv City Clinical Oncological Center, Kyiv

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02366143 - A Study of Atezolizumab in Combination With Carboplatin Plus (+) Paclitaxel With or Without Bevacizumab Compared With Carboplatin+Paclitaxel+Bevacizumab in Participants With Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter