Treatment of Liver Metastases With Electrochemotherapy (ECTJ) Phase II

PHASE2CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

September 30, 2013

Primary Completion Date

October 31, 2018

Study Completion Date

October 31, 2018

Conditions
Liver Metastases
Interventions
PROCEDURE

Electrochemotherapy

Treatment procedure: anesthesia, positioning of electrodes, intravenous in bolus administration of bleomycin, within 8-30 min after administration of bleomycin application of electric pulses, removal of electrodes.

DEVICE

Cliniporator Vitae®

Positioning of electrodes, within 8-30 min after administration of bleomycin application of electric pulses (8 pulses, duration 100 microseconds, frequency 4 Hz with amplitude adequate to cover the whole treated lesion with electric field necessary for reversible plasma membrane permeabilization), removal of electrodes.

DRUG

Bleomycin PHC 15 e. (United States Pharmacopeia - USP)

Intravenous in bolus administration of bleomycin (15 mg/m2), 8 minutes before application of electric pulses

Trial Locations (4)

1000

Faculty of Electrical Engineering, University of Ljubljana, Slovenia, Ljubljana

Institute of Oncology Ljubljana, Ljubljana

University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana

2000

University Medical Centre Maribor, Maribor, Slovenia, Maribor

All Listed Sponsors
collaborator

University Medical Centre Ljubljana

OTHER

collaborator

University Medical Centre Maribor

OTHER

collaborator

University of Ljubljana

OTHER

lead

Institute of Oncology Ljubljana

OTHER

NCT02352259 - Treatment of Liver Metastases With Electrochemotherapy (ECTJ) Phase II | Biotech Hunter | Biotech Hunter