23
Participants
Start Date
January 29, 2015
Primary Completion Date
May 13, 2020
Study Completion Date
May 13, 2022
Gemcitabine
Given IV
Sorafenib
Given PO
Vorinostat
Given PO
3-Dimensional Conformal Radiation Therapy
Undergo 3D CRT
Intensity-Modulated Radiation Therapy
Undergo IMRT
RosetteSep
Circulating tumor cells (CTCs) will be captured and analyzed, when detected. Pancreatic cancer has been a difficult tumor in which to detect CTCs (41). Utilization of techniques that do not require cell surface marker expression will be explored. Samples will either be analyzed by negative-selection techniques (RosetteSep). Peripheral blood samples will be collected at several time-points for CTC enumeration and to evaluate CD95 density.
DEPfff
Circulating tumor cells (CTCs) will be captured and analyzed, when detected. Pancreatic cancer has been a difficult tumor in which to detect CTCs (41). Utilization of techniques that do not require cell surface marker expression will be explored. Samples will either be analyzed by with the ApoStream dielectrophoretic field-flow fractionation (DEPfff) enrichment device. Peripheral blood samples will be collected at several time-points for CTC enumeration and to evaluate CD95 density.
Virginia Commonwealth University/Massey Cancer Center, Richmond
National Cancer Institute (NCI)
NIH
Virginia Commonwealth University
OTHER