Dexamethasone Regimens for Prophylaxis of Paclitaxel-associated Hypersensitivity Reaction

PHASE3CompletedINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

February 28, 2015

Primary Completion Date

July 30, 2015

Study Completion Date

August 30, 2015

Conditions
Hypersensitivity Reaction
Interventions
DRUG

Intravenous Dexamethasone

Lactose (Placebo) 5 tablets given orally at 12 and 6 hours before paclitaxel infusion and dexamethasone 20 mg (5mg/ml) given intravenously at 30 minutes before paclitaxel infusion

DRUG

Oral Dexamethasone

Dexamethasone 20 mg (4 mg/tablet) or 5 tablets given orally at 12 and 6 hours before paclitaxel infusion and 0.9% NaCL (Placebo) 4 ml given intravenously at 30 minutes before paclitaxel infusion

Trial Locations (1)

10400

Rajavithi Hospital, Bangkok

All Listed Sponsors
collaborator

Chulalongkorn University

OTHER

lead

Department of Medical Services Ministry of Public Health of Thailand

OTHER_GOV

NCT02349763 - Dexamethasone Regimens for Prophylaxis of Paclitaxel-associated Hypersensitivity Reaction | Biotech Hunter | Biotech Hunter