Phase Ib and Phase II Studies of MK-3475 in Combination + for Renal Cell Carcinoma:

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

December 5, 2019

Study Completion Date

December 5, 2019

Conditions
Clear Cell Renal Carcinoma
Interventions
DRUG

MK-3475

Arm A: Phase 1b Cohort 1: 200mg IV; Arm A: Phase 1b Cohort 2: 200mg IV

DRUG

Bevacizumab

Arm A: Phase 1b Cohort 1: 10mg IV; Arm A: Phase 1b Cohort 2: 15mg IV

DRUG

MK-3475

Arm B: Phase II Treatment: 200mg IV

DRUG

Bevacizumab

Arm B: Phase II Treatment: administered at the maximum safe dose of 10mg or 15mg as established in the Phase 1b dose escalation cohort study.

Trial Locations (9)

17033

Penn State Hershey Cancer Institute, Hershey

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48910

Michigan State University, Breslin Cancer Center, Lansing

52242

University of Iowa, Holden Comprehensive Cancer Center, Iowa City

55455

University of Minnesota: Masonic Cancer Center, Minneapolis

60611

Northwestern University, Robert H. Lurie Cancer Center, Chicago

60612

University of Illinois Cancer Center, Chicago

68198

University of Nebraska, Fred and Pamela Buffet Cancer Center, Omaha

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Big Ten Cancer Research Consortium

OTHER

lead

Arkadiusz Z. Dudek, MD

OTHER

NCT02348008 - Phase Ib and Phase II Studies of MK-3475 in Combination + for Renal Cell Carcinoma: | Biotech Hunter | Biotech Hunter