Phase I Dose Escalation of BAY1143572 in Subjects With Acute Leukemia

PHASE1CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

February 19, 2015

Primary Completion Date

September 14, 2016

Study Completion Date

July 30, 2017

Conditions
Leukemia
Interventions
DRUG

Atuveciclib, BAY1143572

The starting dose was 20 mg BAY 1143572 once daily from Cycle 1 Day 1. Each cycle was defined as a period of 28 days. Dosing cycles continued until evidence of progression, unacceptable toxicity, consent withdrawal, or withdrawal from the study at the discretion of the investigator.

Trial Locations (7)

10032

Columbia University Medical Center, New York

29425

Medical University of South Carolina, Charleston

37232

Vanderbilt University Medical Center, Nashville

60596

Universitätsklinikum der Johann Wolfgang Goethe Universität, Frankfurt am Main

02215

Dana-Farber Cancer Institute, Boston

07601

Hackensack University Medical Center, Hackensack

01307

Medizinische Fakultät Carl Gustav Carus, Dresden

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY