Entospletinib Monotherapy and in Combination With Chemotherapy in Adults With Acute Myeloid Leukemia (AML)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

July 1, 2015

Primary Completion Date

September 4, 2018

Study Completion Date

February 21, 2019

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Entospletinib

Tablet(s) administered orally every 12 hours

DRUG

Daunorubicin

60 mg/m\^2 administered intravenously daily on Days 1 to 3 for up to two 14-day induction cycles

DRUG

Cytarabine

100 mg/m\^2 administered intravenously daily on Days 1 to 7 for up to two 14-day cycles

DRUG

Decitabine

20 mg/m\^2 administered intravenously

DRUG

Azacitidine

75 mg/m\^2 administered intravenously or subcutaneously

Trial Locations (17)

60590

Universitätsklinikum Frankfurt Medizinische Klinik II, Frankfurt

97239

Oregon Health & Science University, Portland

Unknown

UCLA, Los Angeles

University of Chicago, Chicago

Loyola University Medical Center, Maywood

Indiana University, Indianapolis

University of Kansas Medical Center Research Institute, Inc, Fairway

Dana Farber Cancer Institute, Boston

Henry Ford Health System, Detroit

Karmanos Cancer Institute, Detroit

Weill Cornell Medical College - New York - Presbyterian Hospital, New York

Duke Cancer Center, Durham

University Hospitals Case Medical Center, Cleveland

Ohio State University, Columbus

Saint Francis Cancer Center, Greenville

Princess Margaret, Toronto

Jewish General Hospital, Montreal

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY