100
Participants
Start Date
February 28, 2015
Primary Completion Date
July 31, 2015
Study Completion Date
July 31, 2015
letrozole-metformin
letrozole 2.5 mg will be given daily from day 3 of the cycle for 5 days + metformin 500 mg three times daily continuously for 3 months unless pregnancy occurred
letrozole-metformin-pioglitazone
letrozole will be given daily from day 3 of the cycle for 5 days + (metformin 850 mg + pioglitazone 15 mg) from the first day of the cycle for 10 days.
transvaginal ultrasound
transvaginal ultrasound will be done from day 10 of the cycle and every other day for monitoring of follicular enlargement.
laboratory investigations
day 3: FSH, LH, TSH, and total testosterone day 12 serum E2 day 21 serum progesterone
faculty of medicine, Cairo University, Cairo
Cairo University
OTHER