Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b

PHASE1CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

March 6, 2015

Primary Completion Date

September 1, 2019

Study Completion Date

November 2, 2019

Conditions
Melanoma
Interventions
DRUG

Pembrolizumab and high dose interferon alfa-2b (HDI)

Pembrolizumab and HDI will be given concurrently during the induction phase of the study for up to 6 weeks from treatment initiation. This is followed by surgery. After recovery from surgery, pembrolizumab and HDI will be reinitiated as maintenance therapy during the maintenance phase of the study.

Trial Locations (2)

14263

Roswell Park Cancer Institute, Buffalo

15232

Hillman Cancer Center, Pittsburgh

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Yana Najjar

OTHER

NCT02339324 - Neoadjuvant Combination Biotherapy With Pembrolizumab and High Dose IFN-alfa2b | Biotech Hunter | Biotech Hunter