NCT02337985View on ClinicalTrials.gov

Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

November 20, 2015

Primary Completion Date

October 2, 2025

Study Completion Date

October 2, 2025

Conditions
AIDS-Related Burkitt LymphomaAIDS-Related Diffuse Large B-cell LymphomaAIDS-Related Plasmablastic LymphomaAIDS-Related Primary Effusion LymphomaHIV InfectionAIDS Related Non-Hodgkin Lymphoma
Interventions
DRUG

Prednisone

Given PO

BIOLOGICAL

Rituximab

Given IV

DRUG

Etoposide

Given IV

DRUG

Doxorubicin Hydrochloride

Given IV

DRUG

Vincristine Sulfate

Given IV

DRUG

Cyclophosphamide

Given IV

BIOLOGICAL

Filgrastim

Given SC

BIOLOGICAL

Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Stem/Progenitor Cells

Given IV

Trial Locations (1)

20892

NCI Lymphoid Malignancies Branch, Bethesda

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER