NCT02332980View on ClinicalTrials.gov

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

PHASE2CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

February 19, 2015

Primary Completion Date

August 10, 2021

Study Completion Date

January 4, 2022

Conditions
Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid TissueRecurrent Grade 1 Follicular LymphomaRecurrent Grade 2 Follicular LymphomaRecurrent Grade 3 Follicular LymphomaRecurrent Lymphoplasmacytic LymphomaRecurrent Marginal Zone LymphomaRecurrent Nodal Marginal Zone LymphomaRecurrent Small Lymphocytic LymphomaRecurrent Splenic Marginal Zone LymphomaRecurrent Waldenstrom MacroglobulinemiaRefractory B-Cell Non-Hodgkin LymphomaRefractory Chronic Lymphocytic LeukemiaRefractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid TissueRefractory Follicular LymphomaRefractory Lymphoplasmacytic LymphomaRefractory Nodal Marginal Zone LymphomaRefractory Small Lymphocytic LymphomaRefractory Splenic Marginal Zone LymphomaRefractory Waldenstrom MacroglobulinemiaRichter SyndromeWaldenstrom Macroglobulinemia
Interventions
DRUG

Ibrutinib

Given PO

DRUG

Idelalisib

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (2)

55905

Mayo Clinic in Rochester, Rochester

85259

Mayo Clinic in Arizona, Scottsdale

Sponsors

Lead Sponsor

Mayo Clinic
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Mayo Clinic

OTHER