PERMAD: Personalized Marker-driven Early Switch to Aflibercept in Patients With Metastatic Colorectal Cancer

PHASE2UnknownINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

March 31, 2015

Primary Completion Date

March 31, 2020

Study Completion Date

March 31, 2021

Conditions
Metastatic Colorectal Cancer
Interventions
BIOLOGICAL

Aflibercept

"Early marker-driven switch of antiangiogenic treatment (bevacizumab to aflibercept) maintaining the chemotherapy backbone until definite radiological progression.~compared to a conventional treatment approach of changing chemotherapy and antiangiogenic agent at time of radiologic progression."

Trial Locations (3)

72764

Klinikum am Steinenberg Reutlingen, Reutlingen

Unknown

University Medical Center Hamburg-Eppendorf, Hamburg

University of Ulm, Ulm

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Hubertus-Wald-Cancer Center Hamburg, Germany

UNKNOWN

collaborator

Sanofi

INDUSTRY

collaborator

Assign Data Management and Biostatistics GmbH

OTHER

lead

University of Ulm

OTHER