A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Combination of Ibrutinib With Nivolumab in Participants With Hematologic Malignancies

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

March 11, 2015

Primary Completion Date

February 9, 2022

Study Completion Date

February 9, 2022

Conditions
Hematologic Neoplasms
Interventions
DRUG

Ibrutinib

Participants will receive oral capsule of ibrutinib once daily as either 420 mg or 560 mg or at recommended Phase 2 dose in any of the cohort.

DRUG

Nivolumab

Participants will receive nivolumab intravenously as 3 mg/kg on Day 1 every cycle of 14 days.

Trial Locations (18)

Unknown

New York

Bedford Park

Darlinghurst

Woolloongabba

Haifa

Jeursalem

Ramat Gan

Tel Aviv

Chorzów

Gdansk

Krakow

Wroclaw

Barcelona

Madrid

Salamanca

Ankara

Istanbul

Izmir

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Janssen Research & Development, LLC

INDUSTRY

NCT02329847 - A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Combination of Ibrutinib With Nivolumab in Participants With Hematologic Malignancies | Biotech Hunter | Biotech Hunter