PK PD of the Enantiomers of Tramadol and O-desmethyltramadol in Elderly and Young Subjects

Tramadol extended release 200 mg: Administration of a single 200mg tramadol extended-release tablet

Subjects were evaluated for perception and tolerance of electrical current. An experimentally induced pain model utilizing electrical stimulation from the FDA approved Neurometer, as the painful stimulus was used to assess Current Perception Threshold and Pain Tolerance Threshold (CP/T) in young and elderly subjects following administration of tramadol and of placebo.

Administration of a single placebo tablet identical in appearance to a 200mg tramadol extended-release tablet