79
Participants
Start Date
December 31, 2014
Primary Completion Date
August 31, 2019
Study Completion Date
March 22, 2024
Methotrexate
methotrexate 3.5 g/m2 on day 1 courses 1, 2,3 of MATRIX regimen
Rituximab
Rituximab 375 mg/m2 as conventional IV infusion on day 0 courses 1, 2,3 (MATRIX regimen) and on day 1 courses 4,5,6 (R-ICE)
Cytarabine
Cytarabine 2 g/m2 every 12 hours, in 3-hr infusion on days 2,3 courses 1, 2,3 (MATRIX regimen)
Thiotepa
Thiotepa 30 mg/m2 in 30 minutes infusion on day 4 courses 1, 2,3 (MATRIX regimen) and 5 mg/kg in 250 ml of saline sol. in 2-hrs infusion every 12 hours on day -5 and -4 of conditioning and ASCT
liposomial cytarabine
Intrathecal liposomial cytarabine 50 mg on day 5 courses 1, 2,3 (MATRIX regimen) and on day 4 courses 4,5,6 (R-ICE)
Etoposide
Etoposide 100 mg/m2/d in 500 mL saline sol. in 30 minutes on day 1-2-3 courses 4,5,6 (R-ICE)
Ifosfamide
Ifosfamide 5 g/m2 in 1.000 mL saline sol. in 24-hour infusion on day 2 courses 4,5,6 (R-ICE)
Carmustine
BCNU (carmustine) 400 mg/m2 in 500 mL glucose 5% sol. in 1-hr infusion on day-6 of conditioning and ASCT
whole brain radiotherapy
whole-brain irradiation 36 Gy + tumor- bed boost 10 Gy in patients with residual disease in the parenchymal brain/cerebellum.
Facultni nemocnice, Brno
FNKV (Facultni Nemocnice Kralovske Vinohrady), Prague
Vseobecna facultni nemocnice v Praze, Prague
Spedali Civili, Brescia
UO Ematologia e CTMO, PO Businco, Cagliari
IRST Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola
UO Ematoliga Ospedale dell'Angelo, Mestre
San Raffaele H Scientific Institute, Milan
Istituto Nazionale Tumori, Milan
Ospedale Maggiore Policlinico, Milan
AOU Policlinico di Modena, Modena
SCDU Ematologia, Novara
Ematologia ed Immunologia Clinica - AO di Padova, Padua
UO Oncoematologia Ospedale Tortora, Pagani
Villa Sofia - Cervello, Palermo
Ematologia AOU, Parma
Ematologia Ospedale S.Maria delle Croci, Ravenna
A.O. Bianchi-Melacrino-Morelli, Divisione di Ematologia, Reggio Calabria
Arcispedale Santa Maria Nuova, Azienda Ospedaliera di Reggio Emilia, Reggio Emilia
Ematologia Università La Sapienza, Roma
IRCCS Istituto Regina Elena (IFO), Roma
Policlinico Universitario Campus Bio-Medico, Rome
IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo
AOU Senese, Siena
AO S.Maria di Terni, Terni
SC Ematologia AO Città della Salute e della Scienza, Torino
UO Ematologia Ospedale Panico, Tricase
AOU Santa Maria della Misericordia, Udine
UOC Ematologia Policlinico Rossi, Verona
Ematologia Ospedale S. Bortolo, Vicenza
Erasmus MC, Rotterdam
Beatson Cancer Center, Glasgow
Liverpool Aintree, Liverpool
UCLH University College London Hospitals NHS foundation trust, London
The Christie Hospital, Manchester
Southampton General Hospital, Southampton
International Extranodal Lymphoma Study Group (IELSG)
OTHER